Aiko TanakaGreat Barrier Reef, AustraliaCompletedExample project

Marine Microbiome Antibiotic Screening

Completed screening of sponge-associated microbes yielding three novel antimicrobial candidates.

Health & BiotechnologyAntibioticsMicrobiomeDrug Discovery

About this project

The proposal reports a concrete outcome (three novel antimicrobial candidates) and appears to rest on sound scientific practice, but lacks public detail on methods, data sharing, governance, and community/benefit-sharing. The score reflects high scientific credibility and likely strong impact, tempered by gaps in open-science, measurability metadata, and equity/transparency documentation.

AI summary by the Ozeaon Climate Intelligence System

Why this integrity score?

The OCIS Integrity Report below explains the reasoning behind the headline score — dimension by dimension — and is readable in full here.

Score Reasoning — Dimensions

The headline score is a weighted sum of six integrity dimensions assessed by the Ozeaon Climate Intelligence System.

Scientific Rigor20% weight
92
Reported successful screening and candidate discovery indicates strong experimental outcomes; however proposal lacks a methods appendix and peer-reviewed citations to fully verify protocols.
Open Science15% weight
82
Some outputs (candidate claims) are reported, but there is no explicit commitment to deposit sequence data, assay protocols, or code in open repositories.
Measurability (dMRV)20% weight
88
Discovery endpoints (isolates, assay results) are inherently measurable, but the proposal omits digital tracking details (sample chain-of-custody, metadata schemas, versioned datasets) needed for robust dMRV.
Additionality & Impact15% weight
90
Finding three novel antimicrobials is clearly additional to business-as-usual and has high potential societal/ecosystem benefit, assuming candidates progress through validation.
Transparency & Governance15% weight
87
The proposal demonstrates outcome delivery but does not describe governance, funding flows, permits, or IP arrangements—reducing transparency confidence.
Community & Equity15% weight
85
No information provided on sample permits, access-and-benefit-sharing (ABS), or local/indigenous engagement; the score assumes some standard ethical compliance but flags missing documentation.

Strengths

Concrete, positive outcome: three novel antimicrobial candidates identified.
Likely rigorous experimental screening workflow (implied by success).
High potential additionality and downstream societal benefit from new antibiotics.
Feasible to implement a strong dMRV pipeline because outputs are concrete (isolates, sequences, assays).

Risks & Gaps

Lack of publicly available methods, raw data, and code reduces reproducibility and reuse.
No stated chain-of-custody, sample metadata standard, or repository deposition plan—impairing dMRV and verification.
No documentation of permits, ABS agreements, or benefit-sharing with source communities/nations.

dMRV Recommendation

Tier

Tier 2 — Enhanced

Cadence

Quarterly reporting of dMRV snapshots (sample intake, assay updates, sequence deposits) plus an end-of-project comprehensive report

Recommended

Yes

The project has concrete, lab-based outputs (isolates, sequences, assays) that are well-suited to digital tracking and verification. An enhanced dMRV tier is appropriate because it requires interoperable metadata, sequence and analytical data deposition, and chain-of-custody to verify novelty and provenance while supporting reproducibility and downstream validation.

Unique sample/isolates registry with persistent IDs and MIxS-compliant metadata (GPS, date, collector, permit references)Raw sequence deposition (metagenomes/16S/whole-genome) to public repositories (NCBI/ENA) with accession linksStandardized bioassay result schemas (CSV/JSON) and QA/QC logs for antimicrobial assaysAnalytical chemistry outputs (LC-MS/MS, NMR) deposited in public metabolomics repositories with spectral librariesVersion-controlled analysis code and workflows (GitHub + Zenodo DOIs) and containerized computational environments

About this project

Generating OCIS summary & integrity report…